• Neurology · Feb 2006

    Case Reports

    Linezolid-associated toxic optic neuropathy.

    • J C Rucker, S R Hamilton, D Bardenstein, C M Isada, and M S Lee.
    • Department of Neurology, Rush University Medical Center, Chicago, IL 60612, USA. janet_rucker@rush.edu
    • Neurology. 2006 Feb 28; 66 (4): 595-8.

    AbstractThe oxazolidinone antimicrobial linezolid is effective against gram-positive bacteria. Although maximal recommended therapy is 28 days, treatment durations greater than this are common. Linezolid may cause reversible optic neuropathy and irreversible peripheral neuropathy after months of treatment. Three cases of linezolid-induced optic and peripheral neuropathy are described, and previously reported cases of linezolid-induced optic neuropathy are reviewed. The mechanism of neural toxicity may be impairment of mitochondrial protein synthesis.

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