Neurology
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The oxazolidinone antimicrobial linezolid is effective against gram-positive bacteria. Although maximal recommended therapy is 28 days, treatment durations greater than this are common. ⋯ Three cases of linezolid-induced optic and peripheral neuropathy are described, and previously reported cases of linezolid-induced optic neuropathy are reviewed. The mechanism of neural toxicity may be impairment of mitochondrial protein synthesis.
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An age bias may exist in the prescription of important secondary-preventive therapies in the elderly. ⋯ After hospitalization for stroke or TIA, no differences in overall optimal treatment prescription of secondary-prevention medications between patients ages > or = 80 and their younger counterparts were observed.
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To examine the prevalence of headache and migraine among women using oral contraceptives (OCs) in a large, cross-sectional population-based study. ⋯ Headache, especially migraine, was more likely among premenopausal women using oral contraceptives containing estrogen.
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Comment Letter Historical Article
The first organ transplant from a brain-dead donor.