• Zhen Ci Yan Jiu · Jan 1994

    [Involvement of purines in analgesia produced by weak electro-acupuncture].

    • C Liu, F Zhao, and L Zhu.
    • Institute of Acupuncture and Moxibustion, China Academy of Traditional Chinese Medicine, Beijing.
    • Zhen Ci Yan Jiu. 1994 Jan 1; 19 (1): 59-62, 54.

    AbstractIn the present investigation the intensity of stimulated electro-acupuncture (EA) was measured by electrophysiological collision technique. In the behavioral experiments, by applying the weak electro-acupuncture pulses (50 Hz, 1-1.5mA), not enough to activated A delta afferent fibers, to Yanglingquan and Xuanzhong points, the latency of nociceptive hind limb withdrawal reflex, but not tail-flick latency was prolonged. Administered intraperitoneally, both theophylline and caffeine, P1-purinergic (adenosine) receptor antagonists, could block the electroacupuncture-induced elevation of the nociceptive thresholds in a dose-effect related manner, whereas dipyridamole, an inhibitor of adenosine release, could shorten the after of electro-acupuncture in a dose dependent way. These results suggest that weak electro-acupuncture may induce analgesia and purines appear to be involved in this process.

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