• Charles Pham Dang, Joël Delécrin, Yann Péréon, Isabelle Falconi, Norbert Passuti, Myriam Malinge, and Michel Pinaud.
• Hôtel-Dieu, University Hospital of Nantes, 44093 France. charles.phamdang@chu-nantes.fr
• J Clin Anesth. 2008 Feb 1; 20 (1): 17-24.

Study ObjectiveTo study the electrophysiologic and clinical effects of epidural morphine combined with either bupivacaine 0.125% or ropivacaine 0.2%.DesignComparative, randomized, double-blind study.SettingsIntensive care unit and hospital ward of a university hospital.Patients18 adult ASA physical status I and II patients with degenerative or idiopathic scoliosis, undergoing posterior spinal fusion with instrumentation.InterventionsPatients received epidural administration of 10-mL bolus of either bupivacaine or ropivacaine followed by a 6-mL/h infusion for 48 hours of unlabeled local anesthetic. In all patients, epidural morphine 5 mg was added daily.MeasurementsAssessment was focused mainly on somatosensory cortical evoked potentials, soleus H-reflex, and F waves. These electrophysiologic data were recorded before and after epidural medications. Second, respiratory rate, Paco(2), visual analog score (VAS), and side effects such as postoperative nausea and vomiting (PONV), gastrointestinal (GI) transit delay, and urinary retention were noted.Main ResultsBupivacaine 0.125% + morphine was given to 9 patients, and ropivacaine 0.2% + morphine was given to 9 other patients. H-reflex, F waves, and somatosensory cortical evoked potential recording remained unchanged across the time of assessment. Respiratory rate and Paco(2) values were normal. VASs were indifferently low at rest, but they were lower with bupivacaine than with ropivacaine on mobilization. The frequency of PONV was indifferently high. No altered GI transit or urinary retention was noted.ConclusionAfter epidural administration during the study conditions, bupivacaine 0.125% and ropivacaine 0.2% combined with morphine allow for neurologic examination.

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