• J Clin Anesth · Aug 2015

    Case Reports

    Dystonic reaction associated with ondansetron administration in a patient with normal pressure hydrocephalus.

    • Jay Diaz-Parlet and Sudhakar Subramani.
    • University of Iowa, Iowa City, IA. Electronic address: jay-diaz-parlet@uiowa.edu.
    • J Clin Anesth. 2015 Aug 1;27(5):423-5.

    AbstractA 77-year-old female with normal pressure hydrocephalus underwent urgent revision of the abdominal component of a ventriculoperitoneal shunt. Upon emergence from an uneventful general anesthetic, the patient exhibited cogwheel rigidity with decerebrate posturing and a markedly irregular respiratory rate. This prohibited extubation and prompted an unplanned intensive care unit admission. Ondansetron was the only medication administered that had previously been associated with dystonic reactions. In a previous procedure, the patient had been given ondansetron without a similar reaction. This presentation may have been provoked by existing pathology such as her underlying normal pressure hydrocephalus and small increases in intracranial pressure.Copyright © 2015 Elsevier Inc. All rights reserved.

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