• Acta Obstet Gynecol Scand · Jan 2009

    The novel ischemia marker 'ischemia-modified albumin' is increased in normal pregnancies.

    • Suleyman Guven, Ahmet Alver, Ahmet Mentese, F Ceylan Ilhan, Mustafa Calapoglu, and Mesut A Unsal.
    • Department of Obstetric and Gynecology, Karadeniz Technical University, Trabzon, Turkey. drsuleymanguven@yahoo.com
    • Acta Obstet Gynecol Scand. 2009 Jan 1; 88 (4): 479-82.

    AbstractThe aim of this prospective case-control study was to determine the change in serum maternal ischemia-modified albumin (IMA) during normal pregnancies. A total of 117 pregnant (first trimester (n=24), second trimester (n=34), and third trimester (n=35)) and non-pregnant healthy women (n=23) were included. Maternal serum IMA, Malondialdehyde (MDA), and albumin levels were measured. Compared with non-pregnant women, the cross-sectional mean IMA levels in pregnant women were significantly increased, while the mean serum MDA and albumin levels were significantly decreased throughout pregnancy. Furthermore, a significant negative correlation between serum IMA and albumin levels (r=-0.354, p<0.001) was found, and there was a weak positive correlation between serum albumin and MDA levels (r=0.334, p<0.001). Serum IMA, which has recently been developed as a clinical marker of ongoing myocardial ischemia, appears to be elevated in normal pregnancy. This may be due to the physiologic oxidative stress state of pregnancy.

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