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- Kai Li, Kai-Yuan Fu, Alan R Light, and Jianren Mao.
- Center for TMD & Orofacial Pain, Peking University School & Hospital of Stomatology, Beijing, PR China.
- J. Neuroimmunol. 2010 Apr 15; 221 (1-2): 25-31.
AbstractIn the present study, intraperitoneal administration of minocycline attenuated enhancing nociceptive behaviors in those rats receiving dual formalin injections (5% formalin followed at 7 days later by 1% formalin). The minocycline treatment did not prevent the increase in OX-42 and MHC class I labeling and morphological changes, but significantly attenuated upregulation of phospho-p38 in activated microglia. These results suggest that the later days of microglial activation with upregulated immune markers in the spinal cord contributes to enhancing long-term pain response by a pathway of p38 activation in microglia.Copyright 2010 Elsevier B.V. All rights reserved.
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