• Susan Garwood, Martin Reeder, Ian Z Mackenzie, and John Guillebaud.
• Nuffield Department of Anaesthesia Oxford University, UK. susan.garwood@yale.edu
• Am. J. Obstet. Gynecol. 2002 Mar 1; 186 (3): 383-8.

ObjectiveThe purpose of this study was to determine whether lidocaine that is instilled onto the Fallopian tubes reduces pain scores in awake patients who undergo laparoscopic sterilization with Filshie clips.Study DesignThis was a prospective, randomized, placebo-controlled, double-blinded, clinical trial study that was approved by our institutional review board.ResultsPain scores (visual analogue scales) were lower in the lidocaine group (n = 12 patients) than in the placebo group (n = 12 patients) at clip application (6 vs 71 mm; P <.0001) and after 15 minutes after operation (15.5 vs 44.5 mm; P <.005). No significant differences occurred at 1-hour after operation or discharge, but more rescue analgesia was required in the placebo group ( P <.05), with more side effects ( P <.05). In a separate group of 20 women, serum lidocaine levels were measured (maximum level, 16.0 micromol/L). Holter monitoring of these patients revealed no significant arrhythmias.ConclusionOne percent lidocaine that is instilled onto the Fallopian tubes reduces pain scores in awake patients who undergo laparoscopic sterilization with Filshie clips.

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