• Xiao-Ping Wu, Yan-Jun Gao, Jun-Le Yang, Min Xu, and Dong-Hai Sun.
• Department of Radiology, The Xi'an Municipal Central Hospital, Affiliated Hospital of Xi'an Jiaotong University, Xi'an, PR China.
• Acta Radiol. 2015 Feb 1; 56 (2): 214-8.

BackgroundSubcortical ischemic vascular dementia (SIVD) is a subtype of dementia associated with abnormalities in the subcortical white matter regions. Recent imaging techniques can be used to detect such abnormalities in vivo.PurposeTo examine morphological changes of the corpus callosum in patients with SIVD by using magnetic resonance imaging (MRI) and diffusion tensor imaging (DTI).Material And MethodsMRI was performed to explore changes of cerebral white matter, especially corpus callosum. Brain matter diffusivity was examined with DTI by measuring the fractional anisotropy (FA). Results of 30 patients diagnosed with SIVD and 30 healthy subjects were analyzed and compared.ResultsThe thicknesses of the genu, the anterior third, middle, and posterior third of the body, and the splenium of the corpus callosum were smaller in SIVD patients compared to healthy controls (0.54 ± 0.08 vs. 0.68 ± 0.09 cm, P = 0.0011; 0.27 ± 0.06 vs. 0.38 ± 0.07 cm, P = 0.002; 0.28 ± 0.05 vs. 0.38 ± 0.08 cm, P = 0.009; 0.18 ± 0.04 vs. 0.26 ± 0.06 cm, P = 0.013; 0.54 ± 0.07 vs. 0.72 ± 0.09 cm, P = 0.003, respectively). The FA values of the genu and splenium of the corpus callosum in patients with SIVD were decreased compared to healthy controls (0.664 ± 0.042 vs. 0.778 ± 0.041, P < 0.001; 0.691 ± 0.038 vs. 0.786 ± 0.039, P = 0.001, respectively).ConclusionPatients with SIVD exhibit corpus callosum atrophy and morphological changes, and these characteristics may be useful for diagnosis.© The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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