• Therapeutic delivery · Feb 2015

    Review

    Formulation design for topical drug and nanoparticle treatment of skin disease.

    • Anthony P Raphael, Gabriela Garrastazu, Fabio Sonvico, and Tarl W Prow.
    • Dermatology Research Centre, School of Medicine, Translational Research Institute, Princess Alexandra Hospital, The University of Queensland, Level 5 West Wing, 37 Kent Street, Woolloongabba, Brisbane, QLD 4102, Australia.
    • Ther Deliv. 2015 Feb 1; 6 (2): 197-216.

    AbstractThe skin has evolved to resist the penetration of foreign substances and particles. Topical therapeutic and cosmeceutical delivery is a growing field founded on selectively overcoming this barrier. Both the biology of the skin and the nature of the formulation/active ingredient must be aligned for efficient transcutaneous delivery. This review discusses the biological changes in the skin barrier that occur with common dermatological conditions. This context is the foundation for the discussion of formulation strategies to improve penetration profiles of common active ingredients in dermatology. Finally, we compare and contrast those approaches to recent advances described in the research literature with an eye toward the future of topical formulation design.

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