Therapeutic delivery
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Therapeutic delivery · May 2020
EditorialSubdivision of modified-release tablets: state-of-the-art and future perspectives.
Tablet splitting is a practice disseminated among health professionals for dose adjustments, swallowing facilitation or even treatment cost reduction. Nevertheless, tablets not designed for this purpose cause imprecise dosage and stability loss with important therapeutic repercussions. ⋯ The heterogeneity and complexity of these tablets go well beyond a traditional gastroresistant coating tablet, making orientations on the practice of tablet subdivision difficult. This editorial aims to provide a critical and up-to-date evaluation of this scenario based on the most recent studies involving the subdivision of modified-release tablets.
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Happy New Year to all of our readers. Welcome to volume 9 of Therapeutic Delivery. We would like to take the opportunity to look back over 2017, which was another excellent year for us. We thank all our readers, reviewers, authors and Editorial Board members for their continued support and very much look forward to working with all our contributors again in 2018.
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Therapeutic delivery · Jan 2016
Editorial Historical ArticleAntibody-drug conjugates: targeted delivery and future prospects.
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Therapeutic delivery · Feb 2015
ReviewPain management via local anesthetics and responsive hydrogels.
Acute and chronic pain control is a significant clinical challenge that has been largely unmet. Local anesthetics are widely used for the control of post-operative pain and in the therapy of acute and chronic pain. ⋯ Recently, injectable responsive hydrogels raise significant interest for the localized delivery of anesthetic molecules. This paper discusses the potential of injectable hydrogels to prolong the action of local anesthetics.
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Therapeutic delivery · Feb 2015
ReviewFormulation design for topical drug and nanoparticle treatment of skin disease.
The skin has evolved to resist the penetration of foreign substances and particles. Topical therapeutic and cosmeceutical delivery is a growing field founded on selectively overcoming this barrier. ⋯ This context is the foundation for the discussion of formulation strategies to improve penetration profiles of common active ingredients in dermatology. Finally, we compare and contrast those approaches to recent advances described in the research literature with an eye toward the future of topical formulation design.