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Ann Fr Anesth Reanim · Jan 1995
Case Reports[Prolonged neuromuscular block after administration of mivacurium caused by plasma psueudocholinesterase deficiency].
- E Kaiser, D Petit, J F Quinot, A Suppini, and M Sallaberry.
- Département d'Anesthésie-Réanimation-Centre de brûlés, Hôpital d'Instruction des Armées Sainte-Anne, Toulon Naval.
- Ann Fr Anesth Reanim. 1995 Jan 1; 14 (6): 505-7.
AbstractMivacurium is a new neuromuscular blocking agent with a short acting time of about 30 min, due to a fast hydrolysis by pseudocholinesterases. This metabolism carries a risk for prolonged neuromuscular block in case of an acquired or congenital pseudocholinesterase deficiency. We report the case of a 75-year-old woman who experienced a neuromuscular block prolonged for 10 h after a single dose of 0.35 mg.kg-1 of mivacurium, because of a major pseudocholinesterase (1800 UI.L-1, normal value: 5400-13200 UI.L-1). The likely cause was a congenital deficiency by a homozygote genetic mutation, as usual causes of an acquired deficiency had been eliminated.
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