• Conf Proc IEEE Eng Med Biol Soc · Jan 2013

    Model-based respiratory mechanics to titrate PEEP and monitor disease state for experimental ARDS subjects.

    • Erwin J van Drunen, Yeong Shiong Chiew, J Geoffrey Chase, Bernard Lambermont, Nathalie Janssen, and Thomas Desaive.
    • Conf Proc IEEE Eng Med Biol Soc. 2013 Jan 1; 2013: 5224-7.

    AbstractModelling the respiratory mechanics of mechanically ventilated (MV) patients can provide useful information to guide MV therapy. Two model-based methods were evaluated based on data from three experimental acute respiratory distress syndrome (ARDS) induced piglets and validated against values available from ventilators. A single compartment lung model with integral-based parameter identification was found to be effective in capturing fundamental respiratory mechanics during inspiration. The trends matched clinical expectation and provided better resolution than clinically derived linear model metrics. An expiration time constant model also captured the same trend in respiratory elastance. However, the assumption of constant resistance and a slightly higher fitting error results in less insight than the single compartment model. Further research is required to confirm its application in titrating to optimal MV settings.

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