• Ann Pharmacother · May 2004

    Case Reports

    Transitory ataxia related to topically administered lidocaine.

    • Pascal Perney, François Blanc, Georges Mourad, Jean-Pierre Blayac, and Dominique Hillaire-Buys.
    • Service de Médecine Interne E, Hôpital Saint Eloi, Faculté de Médecine de Montpellier, Montpellier, France. p-perney@chu-montpellier.fr
    • Ann Pharmacother. 2004 May 1; 38 (5): 828-30.

    ObjectiveTo report 2 cases of transitory cerebellar ataxia related to lidocaine administered topically for endoscopy. case summaries: Two patients developed transitory cerebellar ataxia a few minutes after local anesthesia using lidocaine 10% spray and lidocaine 2% orally for a bronchoscopy and transesophageal echocardiography. This effect completely disappeared in 3-5 hours. In neither case was an alternate etiology of cerebellar ataxia identified. The second patient had previously experienced a similar reaction to lidocaine.DiscussionSeveral central neurologic effects of lidocaine have been reported, but until now, only few cases of cerebellar ataxia. In these 2 cases, the Naranjo probability scale indicated that a probable and a highly probable relationship existed between lidocaine administration and the transitory cerebellar ataxia.ConclusionsCerebellar ataxia may occur after local anesthesia with lidocaine; therefore, care must be taken to avoid overdose, even when administered topically.

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