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Case Reports
Diazepam by continuous intravenous infusion for status epilepticus in anticonvulsant hypersensitivity syndrome.
- R J Bertz and D L Howrie.
- Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, PA 15261.
- Ann Pharmacother. 1993 Mar 1; 27 (3): 298-301.
ObjectiveTo report a case of status epilepticus in a patient with anticonvulsant hypersensitivity syndrome (AHS) that was controlled successfully using continuous intravenous infusion diazepam. AHS and alternatives for treatment of status epilepticus are also reviewed.DesignSingle case report.Setting217-bed children's university hospital.PatientFour-year-old, 20-kg girl, diagnosed with idiopathic tonic-clonic epilepsy, who developed AHS to phenobarbital and phenytoin and status epilepticus unresponsive to lorazepam.ResultsDiazepam intravenous infusion at dosages titrated to 8 mg/h was used successfully to control seizures for eight days until signs and symptoms of AHS had resolved and maintenance therapy with valproic acid was started.ConclusionsContinuous intravenous infusion diazepam is a reasonable therapeutic choice for the management of status epilepticus in a patient with AHS when traditional therapy such as phenytoin and phenobarbital cannot be used.
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