• Biomarkers · Jan 2015

    Chromogranin A levels and mortality in patients with severe sepsis.

    • Chih-Hsin Hsu, Luis F Reyes, Carlos J Orihuela, Ricardo Buitrago, Antonio Anzueto, Nilam J Soni, Stephanie Levine, Jay Peters, Cecilia A Hinojosa, Stefano Aliberti, Oriol Sibila, Alejandro Rodriguez, James D Chalmers, Ignacio Martin-Loeches, Jose Bordon, Jose Blanquer, Francisco Sanz, Pedro J Marcos, Jordi Rello, Jordi Solé-Violán, and Marcos I Restrepo.
    • a University of Texas Health Science Center San Antonio , San Antonio , TX, USA .
    • Biomarkers. 2015 Jan 1; 20 (3): 171-6.

    ContextChromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis.ObjectiveAssess association of CgA levels and mortality risk of severely septic patients.MethodsSerum CgA levels were measured in 50 hospitalized, severely septic patients with organ failure <48 h.ResultsHigher CgA levels trended toward higher ICU and hospital mortality. Patients without cardiovascular disease who died in the ICU had higher median (IQR) CgA levels 602.3 (343.3, 1134.3) ng/ml versus 205.5 (130.7, 325.9) ng/ml, p = 0.01.ConclusionsHigh CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.

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