Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
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Chromogranin A (CgA) is a novel biomarker with potential to assess mortality risk of patients with severe sepsis. ⋯ High CgA levels predict ICU mortality in severely septic patients without prior cardiovascular disease.
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To test the hypothesis whether serum advanced oxidation protein products (AOPP) are associated with increased acute kidney injury (AKI) after cardiopulmonary bypass (CPB) and could serve as a biomarker in this aspect, we performed a prospective cohort study. Thirty-five (22.3%) patients developed AKI, and 32 age- and gender-matched patients without AKI were selected as control. ⋯ An optimal serum AOPP 1 h after CPB cutoff of 69.9 μmol/L had a sensitivity of 74%, specificity of 63% and a positive predictive value of 68% for predicting AKI. These results demonstrated that serum AOPP might be an early biomarker for AKI after CPB.