• Y Yang, H Qiu, and F Guo.
• ICU of Zhongda Hospital, Southeast University, Nanjing 210009, China.
• Zhonghua Jie He He Hu Xi Za Zhi. 2001 Apr 1; 24 (4): 228-30.

ObjectiveTo observe the effect of inverse ratio ventilation (IRV) on hemodynamics and oxygen metabolism in sheep with acute respiratory distress syndrome (ARDS).MethodsTwelve ARDS sheep induced by LPS were admitted to this study, and received mechanical ventilation with volume controlled (VC) and pressure controlled ventilation (PC) (conventional ratio and inverse ratio) at the same level of total positive end expiratory pressure (PEEPt), data of hemodynamics and oxygen metabolism were collected at 30 min after the onset of each mode.ResultsWith PC, peak airway pressure was lower than that with VC, but mean airway pressure was higher with IRV. At the same level of PEEPt, there was no difference in hemodynamics and oxygen metabolism between VC and VC-IRV, same as PC and PC-IRV. But compared with VC, arterial oxygen pressure and arterial oxygen saturation with PC-IRV were lower significantly (P < 0.05).ConclusionPEEPt was a very important factor to improve oxygenation, short-term IRV was not better than VC or PC.

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