• Anticancer research · Feb 2010

    The relationship between obesity and cancer mortality in type 2 diabetes: a ten-year follow-up study (ZODIAC-21).

    • G W Landman, K J J Van Hateren, N Kleefstra, and H J G Bilo.
    • Diabetes Research Centre, Isala Clinics, PO Box 10400, 8000 GK Zwolle, The Netherlands. g.w.d.landman@isala.nl
    • Anticancer Res. 2010 Feb 1; 30 (2): 681-2.

    BackgroundPatients with type 2 diabetes mellitus (T2DM) as well as patients with obesity have increased cancer mortality. In a previous paper we suggested that there was a trend for decreased mortality in obese individuals with T2DM. The aim of the new analyses was to investigate the same relationship after increasing our sample size and extending our follow-up period.Patients And Methods1353 patients were followed prospectively as part of the ZODIAC study. The cancer mortality rate was evaluated using standardized mortality ratio (SMR) and its association with BMI (kg/m(2)) and obesity (>30 kg/m(2)) with Cox proportional hazard analysis.ResultsAfter a median follow-up time of 9.8 years, 570 patients had died, of whom 122 died from malignancy. The SMR for cancer mortality was 1.47 (95%CI 1.22-1.76). BMI and obesity were not associated with cancer death.ConclusionThe trend towards an inverse relationship between obesity and cancer mortality as reported previously disappeared after increasing sample size and follow-up to 9.6 years.

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