• P Combes, B Fauvage, and C Oleyer.
• Département d'Information Médicale et de Santé Publique, Centre Hospitalier de Roanne, France.
• Intensive Care Med. 2000 Jul 1; 26 (7): 878-82.

ObjectiveTo compare the ventilator-associated pneumonia (VAP) incidence rates in mechanically ventilated patients according to the type of endotracheal suctioning (closed versus open).SettingThe Neurosurgery Intensive Care Unit of the Grenoble University Hospital, France.DesignA prospective randomised study performed after a 6-month period of nursing personnel training.PatientsOne hundred four consecutive patients needing mechanical ventilation for more than 48 h were randomised into two groups. To be eligible, patients had to have no active infection or respiratory affection in their passes. In the Stericath group (S+, n = 54), patients were not disconnected from the ventilator during suctioning. The others were routinely managed (S-, n = 50). In both groups patterns of frequency and duration of suctioning were performed according to a standardised protocol.MeasurementsThe non-adjusted incidence rate of VAP was lower for S+ than for S- (7.32 versus 15.89 per 1000 patient-days, p = 0.07). Multivariate analysis performed using the Cox model showed an adjusted risk of VAP 3.5 times higher in S- (95% CI: 11.00-12.33). The risk being 4.3 higher in patients receiving gastric acid secretion inhibitors (1.08-16.82). In non-censored cases (n = 76) length of ICU stay increased by an average of 16.8 days when VAP was present (p = 0.0008). No adverse effect due to Stericath use was noted and volume of tracheal aspirate was similar between groups (p = 0.178).ConclusionThe use of Stericath reduced the incidence rate of VAP without demonstrating any adverse effect.

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