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- Suelen Adriani Marques, Fernanda Martins de Almeida, Klauss Mostacada, and Ana Maria Blanco Martinez.
- Laboratório de Regeneração Neural e Função, Departamento de Neurobiologia, Fluminense Federal University, Niterói, RJ, Brazil.
- Methods Mol. Biol. 2014 Jan 1; 1162: 149-56.
AbstractExperimental spinal cord injury (SCI) can maintain the continuity of the spinal cord, as in the contusion (e.g., weight-fall) or compression models, or not, when there is a partial or a complete transection. The majority of acute human SCI is not followed by complete transection, but there is a combination of contusion, compression, and possibly partial transection. The method described here is a compressive mouse model that presents a combination of contusion and compression components and has many facilities in its execution. This lesion was established by our group and represents a simple, reliable, and inexpensive clip compression model with functional and morphological reproducibility. In this chapter we describe, step by step, the protocol of this experimental SCI.
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