• Neuroscience · Mar 2017

    Review

    The neural underpinnings of cognitive flexibility and their disruption in psychotic illness.

    • James A Waltz.
    • Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, Baltimore, MD, USA. Electronic address: jwaltz@mprc.umaryland.edu.
    • Neuroscience. 2017 Mar 14; 345: 203-217.

    AbstractSchizophrenia (SZ) has long been associated with a variety of cognitive deficits, including reduced cognitive flexibility. More recent findings, however, point to tremendous inter-individual variability among patients on measures of cognitive flexibility/set-shifting. With an eye toward shedding light on potential sources of variability in set-shifting abilities among SZ patients, I examine the neural substrates of underlying probabilistic reversal learning (PRL) - a paradigmatic measure of cognitive flexibility - as well as neuromodulatory influences upon these systems. Finally, I report on behavioral and neuroimaging studies of PRL in SZ patients, discussing the potentially influences of illness profile and antipsychotic medications on cognitive flexibility in SZ.Copyright © 2016 IBRO. Published by Elsevier Ltd. All rights reserved.

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