• Br J Clin Pharmacol · Sep 1994

    Randomized Controlled Trial Comparative Study Clinical Trial

    Anti-emetic effect of high-dose metoclopramide vs alizapride--a randomised crossover study.

    • K T Seng, C E Tiong, and T C Hiang.
    • Department of Therapeutic Radiology, Singapore General Hospital.
    • Br J Clin Pharmacol. 1994 Sep 1; 38 (3): 282-4.

    AbstractA randomised double-blind crossover study was undertaken to compare the anti-emetic efficacy of alizapride against high dose metoclopramide. A total of 32 patients on cisplatin were randomised to receive either high dose metoclopramide (7 mg kg-1 day-1) or alizapride (5 mg kg-1 day-1). Anti-emetic responses in terms of control of vomiting episodes were similar in both regimens (59%). However, patients showed a statistically significant preference for high dose metoclopramide (P = 0.02). Side effects of both regimens were minimal. We conclude that alizapride is not superior to high dose metoclopramide in controlling cisplatin induced vomiting.

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