British journal of clinical pharmacology
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Br J Clin Pharmacol · Sep 1994
Randomized Controlled Trial Comparative Study Clinical TrialAnti-emetic effect of high-dose metoclopramide vs alizapride--a randomised crossover study.
A randomised double-blind crossover study was undertaken to compare the anti-emetic efficacy of alizapride against high dose metoclopramide. A total of 32 patients on cisplatin were randomised to receive either high dose metoclopramide (7 mg kg-1 day-1) or alizapride (5 mg kg-1 day-1). ⋯ Side effects of both regimens were minimal. We conclude that alizapride is not superior to high dose metoclopramide in controlling cisplatin induced vomiting.