• Arzneimittel Forsch · Jan 2001

    Role of L-arginine/nitric oxide pathway in the antinociceptive activities of morphine and mepyramine in mice.

    • N Abacioğlu, R Ozmen, I Cakici, B Tunçtan, and I Kanzik.
    • Department of Pharmacology, Faculty of Pharmacy, Gazi University, Ankara, Turkey. nabaci@farma.net.tr
    • Arzneimittel Forsch. 2001 Jan 1; 51 (12): 977-83.

    AbstractThe p-benzoquinone (PBQ)-induced abdominal constriction test was used to assess the involvement of L-arginine/nitric oxide (NO) pathway in the antinociceptive activity of the subcutaneously administered H1-receptor antagonist, mepyramine (CAS 59-33-6), and an opioid receptor agonist, morphine (CAS 57-27-2), in mice. Mepyramine (ED50: 5.6 mg/kg) and morphine (ED50: 0.13 mg/kg) produced antinociceptive effects. The NO precursor L-arginine (CAS 1119-34-2) (50 mg/kg) also produced antinociception similar to mepyramine, but significantly less than morphine. The NO synthase (NOS) inhibitor L-NG-monomethylarginine (L-NMMA) (CAS 53308-83-1) (50 mg/kg) did not significantly change p-benzoquinone-induced abdominal constrictions. L-arginine significantly increased the antinociceptive effects of morphine and mepyramine. The antinociceptive activity of morphine, but not that of mepyramine, was completely abolished when combined with L-NMMA. L-NMMA also significantly decreased the antinociception induced by morphine or mepyramine in combination with L-arginine. The present results suggest that morphine and mepyramine could produce peripheral antinociception by the involvement of L-arginine/NO cascade or other related pathways of nociceptive processes induced by NO.

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