• Shuangyan Li, Wenwen Bai, Tiaotiao Liu, Hu Yi, and Xin Tian.
• Laboratory of Neural Engineering, School of Biomedical Engineering/Research Center of Basic Medicine, Tianjin Medical University, Tianjin 300070, China.
• Brain Res. Bull. 2012 Nov 1; 89 (3-4): 115-23.

AbstractCross-frequency coupling (CFC) between the theta (4-12Hz) phase and the amplitude of gamma (30-100Hz) oscillations occurs frequently in brain. However, the function of theta-gamma coupling in rat medial prefrontal cortex (mPFC) in working memory remains unclear. To address this issue, we studied 16-channel CFC in local field potentials (LFPs) recorded from the mPFC of over-trained rats as they performed a Y-maze working memory task. During this course, the amplitude of the low gamma subband (30-60Hz) was more strongly modulated by theta phase during the correct trials than in the error ones. Meanwhile, more channels showed higher theta-low gamma coupling levels during the correct performance. By contrast, the strength of theta-high gamma coupling did not significantly increase during the working memory task in both correct and error trials, indicating an insignificant correlation with the performance validity. These findings suggest a role of mPFC theta-low gamma coupling in working memory.Copyright © 2012 Elsevier Inc. All rights reserved.

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