• Roberto De Simone, Angelo Ranieri, Silvana Montella, Mario Marchese, Pasquale Persico, and Vincenzo Bonavita.
• Headache Centre, Department of Neurological Sciences, University of Naples Federico II, via Pansini 5, 80131 Naples, Italy. rodesimo@unina.it
• Neurol. Sci. 2012 May 1; 33 Suppl 1: S21-5.

AbstractThe recently advanced hypothesis that idiopathic intracranial hypertension without papilledema (IIHWOP) is a powerful risk factor for the progression of pain in individuals prone to episodic primary headache implies that IIHWOP is much more prevalent than it is believed to be in the general population and that it can run almost asymptomatic in most of the affected individuals. In this review, we discuss the evidence available supporting that: (a) sinus venous stenosis-associated IIHWOP is much more prevalent than believed in the general population and can run without symptoms or signs of raised intracranial pressure in most of individuals affected, (b) sinus venous stenosis is a very sensitive and specific predictor of intermittent or continuous idiopathic intracranial hypertension with or without papilledema, even in asymptomatic individuals, (c) in primary headache prone individuals, a comorbidity with a hidden stenosis-associated IIHWOP represents a very common, although largely underestimated, modifiable risk factor for the progression and refractoriness of headache.

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