• Medical hypotheses · Jan 2006

    Altered electrical activity of fibrillation process following thrombolytic therapy in out-of-hospital cardiac arrest patients with sustained ventricular fibrillation.

    • Wolfgang Lederer, Christoph J Schlimp, Thomas Niederklapfer, and Anton Amann.
    • Department of Anaesthesiology and Critical Care Medicine, Anaesthesiology Research Laboratory, Innsbruck Medical University, Anichstr. 35, A-6020 Innsbruck, Austria. wolfgang.lederer@uibk.ac.at
    • Med. Hypotheses. 2006 Jan 1; 67 (2): 333-5.

    AbstractThe likelihood of successful defibrillation in patients with sustained ventricular fibrillation (VF) is increased after administering thrombolytics during cardiopulmonary resuscitation (CPR). While dissolution of coronary artery thrombosis resolves the underlying cause of myocardial infarction in the majority of patients, improved microcirculatory reperfusion and alteration of the electrical activity of the fibrillation process may increase the likelihood of restoring spontaneous circulation in cardiac arrest patients. Electrocardiography is a sensitive means of displaying current myocardial perfusion in VF using changes in the frequency and amplitude of fibrillation. Our hypothesis postulates that thrombolytic therapy during CPR increases fibrillation frequency, fibrillation amplitude and amplitude spectrum area, thus improving ventricular fibrillation status and the chance of successful defibrillation.

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