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J Assoc Physicians India · Jan 2009
Case ReportsIsoniazid toxicity presenting as status epilepticus and severe metabolic acidosis.
- Yojana A Gokhale, Meghna S Vaidya, A D Mehta, and N N Rathod.
- Department of Internal Medicine, Lokmanya Tilak Municipal Medical College and General Hospital, Sion, Mumbai - 400 022.
- J Assoc Physicians India. 2009 Jan 1; 57: 70-1.
AbstractIsoniazid (INH) is an integral component of treatment of tuberculosis. An acute overdose is potentially fatal and is characterized by the clinical triad of repetitive seizures unresponsive to the usual anticonvulsants, metabolic acidosis with a high anion gap and coma. The diagnosis of INH overdose should be considered in any patient who presents to emergency medical services (EMS) with the triad. We report a patient presenting with multiple generalised tonic clonic (GTC) convulsions with severe metabolic acidosis as a manifestation of INH toxicity.
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