• A Sen, B Erdivanli, Y Tomak, and A Pergel.
• Recep Tayyip Erdogan University, Medical Faculty, Department of Anaesthesiology and Reanimation, Rize, Turkey.
• J Clin Anesth. 2016 Aug 1; 32: 208-13.

Study ObjectiveTo compare sugammadex with conventional reversal of neuromuscular block in terms of postoperative gastrointestinal motility.DesignDouble blinded, randomized, controlled clinical trial.SettingOperating room, postoperative recovery area.PatientsSeventy-two patients with ASA physical status I or II, scheduled for total thyroid surgery were studied.InterventionsWhen 4 twitches were observed on train-of-four stimulation, neuromuscular block was reversed conversatively in the control group, and with sugammadex in the study group.MeasurementsTime to first flatus and feces, incidence of postoperative nausea, vomiting, diarrhea and constipation were collected.Main ResultsMedian time of first flatus was 24 hours (18-32 [10-36]) in the neostigmine group, and 24 (18-28 [12-48]) in the sugammadex group (P > .05). Median (IQR) time of first feces was 24 hours (18-36 [10-48]) in neostigmine group, 32 hours (28-36 [12-72]) in sugammadex group (P > .05). There were no occurrences of nausea, vomiting, diarrhea, or constipation.ConclusionsSugammadex may be safely used in cases where postoperative ileus is expected.Copyright © 2016 Elsevier Inc. All rights reserved.

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