• Am. J. Respir. Crit. Care Med. · Aug 2016

    Review

    Acute Exacerbation of Idiopathic Pulmonary Fibrosis: An International Working Group Report.

    • Harold R Collard, Christopher J Ryerson, Tamera J Corte, Gisli Jenkins, Yasuhiro Kondoh, David J Lederer, Joyce S Lee, Toby M Maher, Athol U Wells, Katerina M Antoniou, Juergen Behr, Kevin K Brown, Vincent Cottin, Kevin R Flaherty, Junya Fukuoka, David M Hansell, Takeshi Johkoh, Naftali Kaminski, Dong Soon Kim, Martin Kolb, David A Lynch, Jeffrey L Myers, Ganesh Raghu, Luca Richeldi, Hiroyuki Taniguchi, and Fernando J Martinez.
    • 1 Department of Medicine, University of California San Francisco, San Francisco, California.
    • Am. J. Respir. Crit. Care Med. 2016 Aug 1; 194 (3): 265-75.

    AbstractAcute exacerbation of idiopathic pulmonary fibrosis has been defined as an acute, clinically significant, respiratory deterioration of unidentifiable cause. The objective of this international working group report on acute exacerbation of idiopathic pulmonary fibrosis was to provide a comprehensive update on the topic. A literature review was conducted to identify all relevant English text publications and abstracts. Evidence-based updates on the epidemiology, etiology, risk factors, prognosis, and management of acute exacerbations of idiopathic pulmonary fibrosis are provided. Finally, to better reflect the current state of knowledge and improve the feasibility of future research into its etiology and treatment, the working group proposes a new conceptual framework for acute respiratory deterioration in idiopathic pulmonary fibrosis and a revised definition and diagnostic criteria for acute exacerbation of idiopathic pulmonary fibrosis.

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