• Mayo Clinic proceedings · Jul 1997

    Case Reports

    Organizing diffuse alveolar damage associated with progressive systemic sclerosis.

    • T E Muir, H D Tazelaar, T V Colby, and J L Myers.
    • Division of Anatomic Pathology, Mayo Clinic Rochester, MN 55905, USA.
    • Mayo Clin. Proc. 1997 Jul 1; 72 (7): 639-42.

    AbstractDiffuse alveolar damage (DAD) is a relatively nonspecific pattern of acute lung injury that can be observed in a wide range of clinical circumstances. DAD has often been recognized in association with various connective tissue diseases; however, to our knowledge, it has not been previously reported in the setting of progressive systemic sclerosis. Herein we describe two patients with established diagnoses of progressive systemic sclerosis who had development of the acute respiratory distress syndrome. Open-lung biopsy specimens from both patients showed a histologic pattern of DAD with no identifiable cause other than their progressive systemic sclerosis. Our results suggest that DAD should be added to the list of pleuropulmonary complications of progressive systemic sclerosis.

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