• Nature neuroscience · Nov 2002

    Review

    NMDA receptor pathways as drug targets.

    • John A Kemp and Ruth M McKernan.
    • EVOTEC Neurosciences GmbH, Schackenburgallee 114, D-22525 Hamburg, Germany.
    • Nat. Neurosci. 2002 Nov 1; 5 Suppl: 1039-42.

    AbstractSince the mid 1980s, there has been a great deal of enthusiasm within both academia and industry about the therapeutic potential of drugs targeting the NMDA subtype of glutamate receptors. That early promise is just beginning to translate into approvable drugs. Here we review the reasons for this slow progress and critically assess the future prospects for drugs that act on NMDA receptor pathways, including potential treatments for some major disorders such as stroke and Alzheimer's disease, for which effective therapies are still lacking.

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