Nature neuroscience
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Since the mid 1980s, there has been a great deal of enthusiasm within both academia and industry about the therapeutic potential of drugs targeting the NMDA subtype of glutamate receptors. That early promise is just beginning to translate into approvable drugs. Here we review the reasons for this slow progress and critically assess the future prospects for drugs that act on NMDA receptor pathways, including potential treatments for some major disorders such as stroke and Alzheimer's disease, for which effective therapies are still lacking.
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Nature neuroscience · Nov 2002
ReviewConnecting cortex to machines: recent advances in brain interfaces.
Recent technological and scientific advances have generated wide interest in the possibility of creating a brain-machine interface (BMI), particularly as a means to aid paralyzed humans in communication. Advances have been made in detecting neural signals and translating them into command signals that can control devices. ⋯ Additional research findings explore the possibility of using computers to return behaviorally useful feedback information to the cortex. Although significant scientific and technological challenges remain, progress in creating useful human BMIs is accelerating.