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- Oliver Gautschi, Solange Peters, Vincent Zoete, Franziska Aebersold-Keller, Klaus Strobel, Bernhard Schwizer, Astrid Hirschmann, Olivier Michielin, and Joachim Diebold.
- Department of Medical Oncology, Luzerner Kantonsspital, Luzern, Switzerland. Electronic address: oliver.gautschi@luks.ch.
- Lung Cancer. 2013 Nov 1; 82 (2): 365-7.
AbstractBRAF V600E is an emerging drug target in lung cancer, but the clinical significance of non-V600 BRAF mutations in lung cancer and other malignancies is less clear. Here, we report the case of a patient with metastatic lung adenocarcinoma with BRAF G469L mutation refractory to vemurafenib. We calculated a structure model of this very rare type of mutated BRAF kinase to explain the molecular mechanism of drug resistance. This information may help to develop effective targeted therapies for cancers with non-V600 BRAF mutations.Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
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