• Yasuyoshi Sakurai, Michiko Uchida, Junko Aiba, Fumiaki Mimura, Midori Yamaguchi, and Masaya Kakumoto.
• Masui. 2014 Mar 1; 63 (3): 320-3.

BackgroundAlthough magnesium can potentially shorten onset time of a muscle relaxant, it is unclear whether it does shorten the onset time of rocuronium for patients in cesarean delivery (CD). Thus the purpose of this study is to compare the onset time of rocuronium in patients with or without preoperative magnesium treatment.MethodsIn 9 CD patients without magnesium (CD group) and 8 CD patients with magnesium (CD-Mg group), neuromuscular function was continuously assessed with acceleromyography immediately after induction of general anesthesia with intravenous injection of thiopental (4-5 mg x kg(-1)) and rocuronium (0.6 mg x kg(-1)). Onset time of muscle relaxation, defined by the time from rocuronium bolus injection until complete absence of twitch height, was measured.ResultsThe onset time of both groups did not significantly differ (50 +/- 10 seconds vs. 51 +/- 11 seconds; P = 0.93, unpaired t-test). Median magnesium concentration, 5.2 mg x dl(-1) (3.8-6.3), and the onset time of CD-Mg group did not correlate magnesium concentrations (P = 0.23, Pearson's correlation coefficient test).ConclusionsMagnesium did not shorten the onset time of rocuronium 0.6 mg x kg(-1) in CD patients.

22 keywords...

hide…