• Pietro Litta, Sara Fantinato, Francesco Calonaci, Erich Cosmi, Marco Filippeschi, Irene Zerbetto, Felice Petraglia, and Pasquale Florio.
• Department of Gynecological Science and Human Reproduction, University of Padua, School of Medicine, Padua, Italy.
• Fertil. Steril. 2010 Oct 1; 94 (5): 1882-6.

ObjectiveTo compare the effectiveness and safety of harmonic scalpel versus electrosurgery to reduce blood loss during laparoscopic myomectomy.DesignProspective randomized controlled study.SettingTertiary referral centers for gynecological care.Patient(S)One hundred sixty consecutive premenopausal women with symptomatic uterine leiomyomata who were assigned to one of the two treatment groups (a total of 80 patients in each group): treatment with electrosurgery devices with a vasoconstrictive solution (50 mL of saline solution and 0.5 mL of epinephrine [1/2 vial of 1 mg/mL]; group A) or harmonic scalpel (group B).Intervention(S)Laparoscopic myomectomy.Main Outcomes Measure(S)The global operative time, the time spent for myoma enucleation and for suturing uterine wall defects, and intraoperative blood loss as well as the surgical difficulty degree and postoperative pain at 24 and 48 hours after the laparoscopic procedure.Result(S)No relevant intra- or postoperative complications were observed in either group. The degree of pain 24 hours after surgery was significantly lower in patients in whom the harmonic scalpel was used. The degree of surgical difficulty did not differ between groups, but the global operative time was significantly shorter in the harmonic scalpel group.Conclusion(S)The use of the harmonic scalpel for laparoscopic myomectomy is associated with low total operative time, low intraoperative blood loss, and low postoperative pain, with no increase in surgical difficulty.Copyright © 2010 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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