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Ann Med Interne (Paris) · Feb 2003
Review Comparative Study[Progress and stagnation in chemotherapy protocols for primary osteosarcoma].
- Nicole Delépine, Salwa Alkallaf, Hélène Cornille, Barbara Markowska, and Gérard Delépine.
- Unité d'Oncologie Pédiatrique et de l'Adulte Jeune, Hôpital Avicenne, 125, rue de Stalingrad, 93000 Bobigny Cedex. nicole.delepine@wanadoo.fr
- Ann Med Interne (Paris). 2003 Feb 1; 154 (1): 12-24.
AbstractThirty years ago, osteosarcoma of a limb meant amputation and death. Two years after diagnosis, 80% of the patients died from pulmonary metastases, despite early amputation. In 2002, more than 70% of these patients can be cured. Successful cure requires adequate and early management centered on en-bloc resection by a specialized surgeon, followed by a long, expensive, and adapted chemotherapy. The cornerstone is high-dose methotrexate. We present data accumulated over the last 30 years on the treatment of osteosarcoma and point out the fundamental steps of this success story.
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