Annales de médecine interne
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Ann Med Interne (Paris) · Feb 2003
Review Comparative Study[Progress and stagnation in chemotherapy protocols for primary osteosarcoma].
Thirty years ago, osteosarcoma of a limb meant amputation and death. Two years after diagnosis, 80% of the patients died from pulmonary metastases, despite early amputation. ⋯ The cornerstone is high-dose methotrexate. We present data accumulated over the last 30 years on the treatment of osteosarcoma and point out the fundamental steps of this success story.