• Kathryn Breaker, Mary Naam, Francisco G La Rosa, Insley P Flaig, and Thomas W Flaig.
• Department of Medicine, School of Medicine, University of Colorado, Aurora, Colorado 80045, USA.
• Dermatol Surg. 2013 Jul 1; 39 (7): 981-7.

BackgroundSeveral case series have reported an association between sorafenib and the development of skin cancer, but they differ in the reported rapidity of skin cancer onset and the frequency of recurrence with ongoing multikinase inhibitor (MKI) treatment.ObjectiveTo compare the presentation and incidence of skin cancer in patients with renal cell carcinoma (RCC) treated with sorafenib and sunitinib.Materials And MethodsThis retrospective study reviewed the records of 69 patients with RCC treated with sorafenib or sunitinib at the University of Colorado Hospital between January 2005 and July 2009.ResultsSeven patients treated with MKI developed skin cancer (5 (13.5%) with sorafenib, 2 (6.3%) with sunitinib; 5 squamous cell carcinomas (SCC), 3 basal cell carcinomas (BCC)); all developed in sun-exposed areas during first-line MKI therapy. The median time from the start of MKI therapy until observation of a skin cancer lesion was 13.5 months.ConclusionWe observed more cases of skin cancer during sorafenib treatment than during sunitinib treatment for advanced RCC; median MKI treatment duration before the identification of skin cancer was longer than 1 year.© 2013 by the American Society for Dermatologic Surgery, Inc. Published by Wiley Periodicals, Inc.

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