• Jose De Andres, Luciano Perotti, Vincent Luis Villaneuva-Perez, Juan Marcos Asensio-Samper, and Gustavo Fabregat-Cid.
• Multidisciplinary Pain Management Department of Valencia University General Hospital, Valencia, Spain. deandres_jos@ gva.es
• Pain Physician. 2013 Mar 1;16(2):145-53.

BackgroundNeuromodulation is an effective and reversible treatment option for chronic intractable pain. Spinal cord stimulation (SCS) represents a field of application of neuromodulation and is known to be effective for several conditions including complex regional pain syndrome (CRPS), failed back surgery syndrome (FBSS), and chronic leg and back pain. SCS has some technical limitations that can be bypassed through retrograde neuromodulation.ObjectiveTo examine the safety and efficacy of retrograde neuromodulation in consecutive patients with neuropathic pain in the perineum or lower limb.Study DesignProspective chart review analyzing one year of retrograde stimulation in our department.MethodsWe present a series of 10 patients who underwent retrograde neuromodulation at the University General Hospital of Valencia (Spain). We analyzed the variables that can improve the outcome and help physicians choose retrograde neuromodulation.ResultsSeven of 10 patients had an effective treatment and 3 patients had an ineffective stimulation. In the group with the effective treatment the most represented type of pain was radiculopathy and perineal pain.LimitationsThis is a prospective, single-center study with a relatively small number of patients and no control group.ConclusionRetrograde neuromodulation seems to be effective in patients that present with a well localized pain with a clear dermatome distribution. We found retrograde neuromodulation to be effective in radiculopathy related to FBSS. We found it to be limited in the treatment of perineal pain probably due to technical limitations and anatomical reasons besides the lack of knowledge of the etiology of this pain model and the exact mechanisms of action of neuromodulation.

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