• Semin Cutan Med Surg · Jun 2014

    Review

    Precision medicine and precision therapeutics: hedgehog signaling pathway, basal cell carcinoma and beyond.

    • Shalini V Mohan and Anne Lynn S Chang.
    • Department of Dermatology, Stanford University School of Medicine, Redwood City, CA USA. Email: alschang@stanford.edu.
    • Semin Cutan Med Surg. 2014 Jun 1; 33 (2): 68-71.

    AbstractPrecision medicine and precision therapeutics is currently in its infancy with tremendous potential to improve patient care by better identifying individuals at risk for skin cancer and predict tumor responses to treatment. This review focuses on the Hedgehog signaling pathway, its critical role in the pathogenesis of basal cell carcinoma, and the emergence of targeted treatments for advanced basal cell carcinoma. Opportunities to utilize precision medicine are outlined, such as molecular profiling to predict basal cell carcinoma response to targeted therapy and to inform therapeutic decisions.

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