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- Barry A Mizock.
- Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA. bmizock@earthlink.net
- Nutrition. 2010 Jul 1; 26 (7-8): 701-7.
AbstractDietary supplementation with nutrients that have physiologic effects on immune function has been shown to be beneficial in subsets of patients with surgical and medical critical illness. However, several meta-analyses have suggested potential harm when immune nutrients are used inappropriately. This has led to concern among clinicians that in turn has curtailed the more widespread use of immunonutrition as a therapeutic modality. This article discusses the mechanisms by which immune nutrients can be used to modulate alterations in innate and acquired immunity associated with critical illness. In addition, recent evidence-based clinical practice guidelines for use of immunonutrition in adults is reviewed as a means to clarify some of the more controversial issues and provide a "roadmap" for the practitioner.2010 Elsevier Inc. All rights reserved.
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