• Handb Clin Neurol · Jan 2014

    Review

    Methodology for conduct of epidemiologic surveys and randomized controlled trials of diabetic polyneuropathy.

    • Peter James Dyck.
    • Peripheral Neuropathy Research Laboratory, Mayo Clinic, Rochester, MN, USA. Electronic address: dyck.peter@mayo.edu.
    • Handb Clin Neurol. 2014 Jan 1; 126: 335-8.

    AbstractThis chapter outlines: (1) the reasons why epidemiologic surveys and randomized controlled clinical trials (RCTs) of diabetic polyneuropathy (DPN) are difficult and expensive, and often poorly done, (2) primary and secondary neuropathy end points, (3) single versus composite neuropathic end points, (4) adequate reference values from study of population representative cohorts, and (5) the issue of clinical proficiency.

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