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Ann Fr Anesth Reanim · Jan 1995
Case Reports[Cephalic cancer pain controlled by intraventricular administration of morphine and clonidine].
- J F Loriferne, I Souchal Delacour, S Rostaing, J P N'Guyen, and F Bonnet.
- Service d'Anesthésie-Réanimation, Hôpital Saint-Camille, Bry-sur-Marne.
- Ann Fr Anesth Reanim. 1995 Jan 1; 14 (2): 233-6.
AbstractA 47-year-old woman suffered from a pharyngeal cancer causing pain only poorly relieved by high doses of oral morphine. Oral administration was switched to the intracerebroventricular (ICV) route but pain relief was only transient despite a daily dosage up to 1.5 mg of morphine. Finally an effective pain relief was achieved with increasing doses of clonidine (5 to 30 micrograms) in combination with morphine (1.5 mg) by ICV route. Neither arterial hypotension nor sedation occurred and the patient recovered transiently a better quality of life.
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