• Zhongguo Zhong Xi Yi Jie He Za Zhi · Feb 2006

    Randomized Controlled Trial

    [Effects of raw rhubarb on plasma D-lactate and procalcitonin expressions in patients with sepsis].

    • Xue-ling Fang, Qiang Fang, and Jian-jun Luo.
    • Intensitive Care Unit of the First Affliated Hospital, College of Medical Sciences, Zhejiang University, Huangzhou 310003. zzg@mail.hz.zj.cn
    • Zhongguo Zhong Xi Yi Jie He Za Zhi. 2006 Feb 1; 26 (2): 128-30.

    ObjectiveTo investigate the effects of raw rhubarb (RR) on levels of plasma D-lactate and procalcitonin in patients with sepsis.MethodsForty patients with sepsis enrolled were randomly divided into two groups, the RR group (n=18, treated with RR 9 g/d) and the control group (n=22, treated with conventional treatment). Plasma procalcitonin and D-lactate were determined before and after treatment.ResultsBefore treatment, there was no significant difference in the levels of plasma procalcitonin and D-lactate between the two groups (procalcitonin: 6.50 +/- 2.37 microg/L vs 6.98 +/- 2.89 microg/L; D-lactate: 0.18 +/- 0.05 mmol/L vs 0.19 +/- 0.06 mmol/L, P > 0.05). However, after treatment, two indexes in the RR group were significantly lower than those in the control group (procalcitonin: 4.11 +/- 1.40 microg/L vs 2.21 +/- 0.61 microg/L; D-lactate: 0.24 +/- 0.06 ng/L vs 0.09 +/- 0.03 ng/L, both P < 0.05).ConclusionRR could ameliorate the intestinal permeability and reduce the shifting of intestinal bacteria, so as to ease the condition of disease in patients with sepsis.

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