• Rev Recent Clin Trials · May 2009

    Review

    Long-term bronchodilator inhaled therapy in COPD: the role of tiotropium bromidum.

    • Sabina A Antoniu.
    • Division of Pulmonary Disease, University of Medicine and Pharmacy Gr. T .Popa, Pulmonary Disease University Hospital, 30 Dr I Cihac Str, Iasi, Romania. sabina.antonela.antoniu@pneum.umfiasi.ro
    • Rev Recent Clin Trials. 2009 May 1; 4 (2): 89-98.

    AbstractChronic obstructive pulmonary disease (COPD) is an inflammatory disease of the lungs in which airways inflammation related mainly to smoking causes progressive airflow obstruction and chronic respiratory symptoms such as dyspnea or cough. COPD therapy in stable state is mainly inhalatory with bronchodilators and inhaled corticosteroids and the regimen depends on disease severity. Inhaled bronchodilators are the mainstay of maintenance therapy in COPD whether given alone or added to other inhaled medications. Current therapeutic guidelines are based on data from studies assessing long-term impact of such therapies on outcome measures such as lung function, survival, exacerbations or health-related quality of life (HRQoL). This is a review discussing the data regarding to inhaled bronchodilators with a focus on a long-acting anticholinergic, tiotropium bromide.

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