• NeuroImage · Apr 2008

    In vivo MRI tracking of exogenous monocytes/macrophages targeting brain tumors in a rat model of glioma.

    • Samuel Valable, Emmanuel L Barbier, Myriam Bernaudin, Simon Roussel, Christoph Segebarth, Edwige Petit, and Chantal Rémy.
    • Inserm, U836, Grenoble, France.
    • Neuroimage. 2008 Apr 1; 40 (2): 973-83.

    AbstractThis study has shown that murine monocytes/macrophages (Mo/Ma) can be labeled simply and efficiently with large, green-fluorescent, micrometer-sized particles of iron-oxide (MPIO). Neither size nor proliferation rate of the Mo/Ma is significantly affected by this labeling. The labeled Mo/Ma have been administered intravenously to rats that had developed a glioma following stereotactic injection of C6 cells. The labeled Mo/Ma were shown to target the brain tumors, a process that could be monitored non-invasively using T2*-weighted MRI. MRI observations were confirmed by Prussian blue staining, lectin staining and fluorescence histology. Overall, the results of this study suggest that the use of Mo/Ma may be envisaged in the clinic for vectorizing therapeutic agents toward gliomas.

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