• Ann Fr Anesth Reanim · Jan 1994

    [Infectious complications linked to the use of Diprivan. Precaution of administration].

    • B Veber.
    • Service de Réanimation des maladies infectieuses, Hôpital Bichat, Claude-Bernard, Paris.
    • Ann Fr Anesth Reanim. 1994 Jan 1; 13 (4): 457-9.

    AbstractIn order to avoid the risk of severe infection by bacterial contamination of propofol, all users of this agent, should be reminded of the required aseptic technique "for the correct use of Diprivan". These points have recently been listed by Zeneca Pharma. They mainly include the following items: 1. Propofol is to be administered immediately after opening the vials and/or ampoules and the duration of the same continuous infusion should not excede 12 hours. 2. Disposable equipment (syringes, infusion sets, 3-way stopcoks, infusion bottles) should be used and restricted to one patient only. 3. One ampoule or vial of diprivan, once opened, must be used for one patient only. The remaining solution must be discarded. 4. Disinfection of the ampoule neck or vial stopper using and antiseptic solution before opening, is a strongly measure recommended. 5. Finally, hand washing should be routine, prior to these manipulations. As far as the above mentioned precautions are strictly followed, this anaesthetic agent may be used safely, even in case of prolonged sedation.

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