• J Assoc Physicians India · Apr 1998

    Comparative Study Clinical Trial

    Herpes zoster and post-herpetic neuralgia--a clinical trial of aspirin in chloroform for anodyne.

    • D K Kochar, R P Agarwal, A Joshi, and B L Kumawat.
    • Department of Medicine, Neurology Section, Sardar Patel Medical College, Bikaner-334 003, India.
    • J Assoc Physicians India. 1998 Apr 1; 46 (4): 337-40.

    AbstractPain associated with Herpes Zoster (HZ) and Post-herpetic Neuralgia (PHN) has been a challenging task to manage with ease. Topical aspirin dissolved in chloroform is an effective means of reducing pain due to HZ and PHN in most patients. The locus of pain origin and analgesia induced by topical aspirin is supposed to be at cutaneous free nerve ending pain receptors. The present study was conduced in fifty two patients of HZ and PHN. Pain intensity before and after the application of drug was measured with help of Sort Form McGill Pain Questionnaire (SE-MPQ). Most of the patients experienced relief of pain within 1-5 minutes after the aspirin-chloroform application. Maximum relief was achieved in about 30-40 minutes and persisted for 5-6 hrs. In the beginning 3-4 applications were required but frequency decreased gradually as the pain abated.

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